Congenic Strain Differences of Renal Malformations in Aci/mna Rats by Introgression of the Chromosomal Region of Buf/mna Rats Containing Pur1
نویسندگان
چکیده
The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
منابع مشابه
Refusal of Food Ingestion of Old Male BUF/Mna Rats in Metabolic Cages
Forty-four percent of old male BUF/Mna rats showed refusal of food intake when they were isolated in metabolic cages.
متن کاملGenetic mapping of the thymoma susceptible locus, Tsr1, in BUF/Mna rats.
BUF/Mna (BUF) rats have been reported to develop spontaneous thymomas in virtually 100% of animals (1–4). The thymomas in BUF rats have been defined as epithelial cell tumors, having varying proportions of lymphocytic components that are non-neoplastic in nature (5,6). These thymomas start to develop in rats at the age of 9 months and they reach their maximum growth by the time the animals are ...
متن کاملExpression quantitative trait loci analysis of 13 genes in the rat prostate.
Differential expression of mRNA among animal strains is one of the mechanisms for their diversity. cDNA microarray analysis of the prostates of BUF/Nac (BUF) and ACI/N (ACI) rats, which show different susceptibility to prostate cancers, found 195 differentially expressed genes. To identify loci that control differential expression of 13 genes with diverse expression levels, their expression lev...
متن کاملLate Breaking Presentations LB1 The Effects of the Rf1 and Rf-2/Bpfh1 Region from the FHH Rat on Renal Damage Susceptibility, Blood Pressure and Renal Autoregulation
Susceptibility to renal damage and hypertension of the Fawn Hooded Hypertensive (FHH) rat have been found to be linked to five renal failure QTLs (Rf1 to Rf5) and two blood pressure QTLs (Bpfh1 and -2). The Rf1, Rf2 and Bpfh1 QTLs are in close vicinity on rat chromosome 1. To directly determine the effects of these QTLs congenic strains were generated carrying the QTLs from FHH on the genomic b...
متن کاملA rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing.
Representational difference analysis (RDA) was applied to isolate chromosomal markers in the rat. Four series of RDA [restriction enzymes, BamHI and HindIII; subtraction of ACI/N (ACI) amplicon from BUF/Nac (BUF) amplicon and vice versa] yielded 131 polymorphic markers; 125 of these markers were mapped to all chromosomes except for chromosome X. This was done by using a mapping panel of 105 ACI...
متن کامل